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Introduction to Protein Structure

Edition:
2nd
Author(s):
Carl Ivar Branden, John Tooze
ISBN:
9780815323044
Format:
Hardback
Publication Date:
December 01, 1998
Content Details:
410 pages
Language:
English

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Paperback
$108.00

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  • About the Book

    Book Summary

    Introduction to Protein Structure provides an account of the principles of protein structure, with examples of key proteins in their biological context generously illustrated in full-color to illuminate the structural principles described in the text. The first few chapters introduce the general principles of protein structure both for novices and for non-specialists needing a primer. Subsequent chapters use specific examples of proteins to show how they fulfill a wide variety of biological functions. The book ends with chapters on the experimental approach to determining and predicting protein structure, as well as engineering new proteins to modify their functions.

    Reviews

      "The strength of the book lies in its beautiful art work and its logical dissection of the baffling complexities of protein structures…admirably concise, lucid and accurate presentations of difficult concepts…invaluable for students…" Nature

      "As an introduction to what proteins look like, how they fold up and how they interact with other molecules, large and small this book has no peer. It will be invaluable to students and research workers." Trends in Biotechnical Sciences

      "As usual, the distillation is authoritative and breathtaking." Tom Alber, University of California, Berkeley

      "It is superb. It gives a terrific overview, with great breadth and a proper and fair weight to the subject it treats." Ken Dill, University of California, San Francisco

  • Contents

    PART 1 BASIC STRUCTURAL PRINCIPLES
    1. The Building Blocks
    2. Motifs of Protein Structure
    3. α-Domain Structures
    4. α/β Structures
    5. β Structures
    6. Folding and Flexibility
    7. DNA Structures  

    PART 2 STRUCTURE, FUNCTION AND ENGINEERING 
    8. DNA Recognition in Procaryotes by Helix-Turn-Helix Motifs
    9. DNA Recognition by Eukaryotic Transcription Factors
    10. Specific Transcription Factors Belong to a Few Families
    11. An Example of Enzyme Catalysis: Serine Proteinases 
    12. Membrane Proteins
    13. Signal Transduction
    14. Fibrous Proteins
    15. Recognition of Foreign Molecules by the Immune System
    16. The Structure of Spherical Viruses
    17. Prediction, Engineering, and Design of Protein Structures
    18. Determination of Protein Structures