Human Molecular Genetics
- Tom Strachan, Andrew Read
- Publication Date:
- April 01, 2010
- Content Details:
- 786 pages | 610 illustrations
Also of Interest
Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.
The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.
- Chapter on model organisms and comparative genomics expanded and updated to include extensive detail on all the major model organisms, as well as more detail on evolution and phylogentic trees.
- Completely rewritten chapter on the study of gene function in the post-genome era reflects new technologies and progress since the previous edition such as ChIP-chip or ChIP-on-chip, ChIPSeq, and TAP-tagging. Up-to-date tables describe all the major publicly accessible databases for transcriptomics, proteomics, protein interactions, and conserved elements and protein domains.
- Expanded coverage of pharmacogenetics with a heavily updated section on susceptibility testing for disease.
- Discussion of the increasing use of mice in human genetics research an dnow mice are becoming more important in studying human disease. Covers recent developments in mouse genetics such as the International Knockout Mouse Consortium (IKMC).
- An extremely comprehensive and up-to-date chapter on both the treatment of genetic disease and the genetic treatment of disease, as well as the use of stem cells to treat disease.
- Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter help readers navigate the wealth of information in this subject.
- End-of-chapter summaries provide readers with an overview of the material presented, allowing for review and assessment of their understanding.
- Clear, yet detailed, full-color illustrations.
- Special Topic Boxes covering ethical, legal and social issues.
- Consistent emphasis on the explanation of principles rather than the presentation of a large number of facts.
- Extensive glossary.
- Index includes names of diseases and disorders.
- Color-coded sections for ease of use.
PART 1: THE BASICS OF DNA, CHROMOSOMES, CELLS, AND DEVELOPMENT
1. Nucleic Acid Structure and Gene Expression
2. Chromosome Structure and Function
3. Genes in Pedigrees and Populations
4. Cells and Cell-Cell Communication
5. Principles of Development
PART 2: ANALYZING THE STRUCTURE AND EXPRESSION OF GENES AND GENOMES
6. Amplifying DNA: Cell-based DNA Cloning and PCR
7. Nucleic Acid Hybridization: Principles and Applications
8. Analyzing the Structure and Expression of Genes and Genomes
PART 3: INVESTIGATING THE HUMAN GENOME AND ITS RELATIONSHIP TO OTHER GENOMES
9. Organization of the Human Genome
10. Model Organisms, Comparative Genomics and Evolution
11. Human Gene Expression
12. Studying Gene Function in the Post-Genome Era
PART 4: HUMAN GENETIC VARIATION AND DISEASES
13. Human Genetic Variability and its Consequences
14. Genetic Mapping of Mendelian Characters
15. Mapping Genes Conferring Susceptibility to Complex Disease
16. Identifying Human Disease Genes and Susceptibility Factors
17. Cancer Genetics
PART 5: APPLIED HUMAN MOLECULAR GENETICS
18. Genetic Testing of Individuals
19. Pharmacogenetics, Personalized Medicine, and Population Screening
20. Genetic Manipulation of Animals for Modeling Disease and Investigating Gene Function
21. Genetic Approaches to Treating Disease
For the following resources verified instructors can visit the resource page for Human Molecular Genetics, 4E.
The Art of Human Molecular Genetics, Fourth Edition
Artwork available in PowerPoint and JPEG formats.
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