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Cell Signaling

Edition:
1st
Author(s):
Wendell Lim, Bruce Mayer, Tony Pawson
ISBN:
9780815342441
Format:
Paperback
Publication Date:
June 15, 2014
Content Details:
412 pages | 340 illustrations
Language:
English

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List Price:   $138.00

  
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  • About the Book

    Book Summary

    Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate.  By emphasizing the common design principles, components, and logic that drives all signaling, the book develops a conceptual framework through which students can understand how thousands of diverse signaling proteins interact with each other in vast interconnected networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery.  It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and provide a comprehensive overview of major eukaryotic signaling pathways.

    Features

      Key Features

      • Provides a conceptual framework through which all signaling pathways can be understood without memorization of details.
      • Attractive and consistent art program with custom-built structures to clarify key concepts in a molecular context.
      • End-of-chapter questions reinforce central concepts while promoting an experimental and inquisitive approach to the subject. Answers are provided online.
      • Pedagogy includes end-of-chapter summaries, references, glossary, and cross-reference icons to make explicit connections between chapters.
      • Cell Signaling Technology® poster included with each book.  The two-sided poster details important signaling pathways.
      • Chapter 12, How Cells Make Decisions, offers a unique visual and interrogative approach that explores four key signaling pathways from the organismal to molecular levels.
      • Chapter 13, Methods for Studying Signaling Proteins and Networks, reviews important experimental methods and approaches in cell signaling.

    Reviews

      The authors pull off the difficult trick of providing both an effective introduction to the basics of cellular signal transduction and a comprehensible and remarkably comprehensive description of the details of specific signaling systems. Cell Signaling focuses solidly on biochemical and biophysical principles of signal transduction, but the work is so accessible and complete that it will provide even upper-level undergraduate students a solid basis for further studies in systems biology. The clarity of the graphic presentations combined with the clarity of the text means that this book will be a well-used tool by any owner, ranging from undergraduate to seasoned researcher.-- CHOICE
  • Contents

    Table of Contents
    1.Overview of Signal Transduction
    2.Principles and Mechanisms of Protein Interactions
    3.Signaling Enzymes and Their Allosteric Regulation
    4.Role of Post-Translational Modifications in Signaling
    5.Subcellular Localization of Signaling Molecules
    6.Small Soluble Signaling Mediators
    7.Lipids and Enzymes that Modify Them
    8.Information Transfer Across the Membrane
    9.Regulated Protein Degradation
    10.Modular Architecture and Evolution of Signaling Proteins
    11.Signaling Devices in Networks
    12.How Cells Make Decisions
    13.Methods for Studying Signaling Proteins and Networks

  • Instructor Resources

    Instructor Resources

    Every copy of the book includes a two-sided "Signal Transduction Pathways" poster created by Cell Signaling Technologies. The poster details forty important signaling pathways.

    For the following resources, verified instructors can visit the resource page for Cell Signaling.

    Artwork in JPEG and PPT formats

  • Student Resources

    Student Resources

    Every copy of the book includes a two-sided "Signal Transduction Pathways" poster created by Cell Signaling Technologies. The poster details forty important signaling pathways.

    Online flashcards and glossary

    Answers to end-of-chapter questions

    PDF of "Signal Transduction Pathways"

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