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Case Studies in Immunology

A Clinical Companion

Raif Geha, Luigi Notarangelo
Publication Date:
October 18, 2011
Content Details:
376 pages

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  • About the Book

    Book Summary

    Case Studies in Immunology, Sixth Edition, presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case.

    Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway’s Immunobiology, Eighth Edition. A marginal icon in Janeway’s Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting.

    The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includes ten new cases:

    • DiGeorge Syndrome
    • Hemophagocytic Lymphohistiocytosis
    • Chediak-Higashi Syndrome
    • Hyper IgE Syndrome
    • Ataxia Telangiectasia
    • Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
    • Severe Congenital Neutropenia
    • Recurrent Herpes Simplex Encephalitis
    • Systemic Onset Juvenile Idiopathic Arthritis
    • Crohn’s Disease


      Key Features:

      • Concise presentation of basic scientific facts and clinical presentation and diagnosis of immunological disorders.
      • Cases are drawn from actual clinical practice and provide open-ended scenarios that leave room for thought and analysis.
      • Case study format presents the mechanisms underlying immunological dysfunction and aids in the diagnosis and treatment of immune disorders.
      • Discussion questions help students move beyond the stated facts to consider the implications of immunological disorders on other aspects of health and disease.
      • Can be used as both a stand-alone review aid or as a companion to Janeway’s Immunobiology, Eighth Edition, and The Immune System, Third Edition.
  • Contents

    Case 1 X-linked Agammaglobulinemia
    Case 2 CD40 Ligand Deficiency
    Case 3 Activation-induced Cytidine Deaminase Deficiency
    Case 4 Common Variable Immunodeficiency
    Case 5 X-linked Severe Combined Immunodeficiency
    Case 6 Adenosine Deaminase Deficiency
    Case 7 Omenn Syndrome
    Case 8 MHC Class II Deficiency
    Case 9 DiGeorge Syndrome
    Case 10 Acquired Immune Deficiency Syndrome (AIDS)
    Case 11 Graft-Versus-Host Disease
    Case 12 MHC Class I Deficiency
    Case 13 X-linked Lymphoproliferative Syndrome
    Case 14 Hemophagocytic Lymphohistiocytosis
    Case 15 Chediak-Higashi Syndrome
    Case 16 Wiskott-Aldrich Syndrome
    Case 17 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
    Case 18 Immune Dysregulation, Polyendocrinopathy, Enteropathy X-linked Disease
    Case 19 Autoimmune Lymphoproliferative Syndrome (ALPS)
    Case 20 Hyper IgE Syndrome
    Case 21 Ataxia Telangiectasia
    Case 22 Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
    Case 23 X-linked Hypohidrotic Ectodermal Dysplasia and Immunodeficiency
    Case 24 Interferon-γ Receptor Deficiency
    Case 25 Severe Congenital Neutropenia
    Case 26 Chronic Granulomatous Disease
    Case 27 Leukocyte Adhesion Deficiency
    Case 28 Recurrent Herpes Simplex Encephalitis
    Case 29 Interleukin 1 Receptor-associated Kinase 4 Deficiency
    Case 30 Congenital Asplenia
    Case 31 Hereditary Angioedema
    Case 32 Factor I Deficiency
    Case 33 Deficiency of the C8 Complement Component
    Case 34 Hereditary Periodic Fever Syndromes
    Case 35 Systemic Onset Juvenile Idiopathic Arthritis
    Case 36 Rheumatoid Arthritis
    Case 37 Systemic Lupus Erythematosus
    Case 38 Mixed Essential Cryoglobulinemia
    Case 39 Crohn’s Disease
    Case 40 Multiple Sclerosis
    Case 41 Autoimmune Hemolytic Anemia
    Case 42 Myasthenia Gravis
    Case 43 Pemphigus Vulgaris
    Case 44 Celiac Disease
    Case 45 Acute Infectious Mononucleosis
    Case 46 Hemolytic Disease of the Newborn
    Case 47 Toxic Shock Syndrome
    Case 48 Lepromatous Leprosy
    Case 49 Acute Systemic Anaphylaxis
    Case 50 Allergic Asthma
    Case 51 Atopic Dermatitis
    Case 52 Drug-induced Serum Sickness
    Case 53 Contact Sensitivity to Poison Ivy


    Figure Acknowledgments


  • Instructor Resources

    Instructor Resources

    For the following resources, verified instructors can visit the resource page for Case Studies in Immunology, Sixth Edition.

    The Art of Case Studies in Immunology
    The artwork of Case Studies in Immunology, 6E are available in PowerPoint and JPEG formats.

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  • Downloads

    Samples & Downloads

    Download the correlation guide for Case Studies In Immunology, 6E and The Immune System, 3E.